IrisPlex and HIrisPlex Eye and Hair Colour DNA Phenotyping Webtool


Welcome to the Department of Genetic Identification of Erasmus MC (formerly known as Department of Forensic Molecular Biology)."

With the advancement of DNA phenotyping as a tool in Forensic and Anthropological usage, we now provide an easy to use interactive website to predict both eye and hair colour from DNA using the IrisPlex and HIrisPlex systems.

Please see the manual for instructions. We hope you enjoy using this tool and find it a useful addition to your analyses. If you have any issues regarding this website, please contact us using the contact form.

The IrisPlex System

GeneSNPAlleleNo. of Alleles
HERC2rs12913832T
OCA2rs1800407A
SLC24A4rs12896399T
SLC45A2rs16891982C
TYRrs1393350T
IRF4rs12203592T
 
Display Predicted Phenotype    Download Predicted Phenotype
 
Predicted phenotype

Instructions

If input allele is not present, put 0 into 'No. of alleles' box
If one is present, heterozygote, put 1 in the box
If the only allele present is the input allele, homozygote, put 2 in the box
If there is a missing SNP. please enter NA
Inputs missing HERC2 rs12913832 will not produce an eye colour prediction result

file upload

example input file (header only, add your own data): IrisPlex.csv

The HIrisPlex System

GeneSNPAlleleNo. of Alleles
MC1Rrs86insAA
MC1Rrs11547464A
MC1Rrs885479T
MC1Rrs1805008T
MC1Rrs1805005T
MC1Rrs1805006A
MC1Rrs1805007T
MC1Rrs1805009C
MC1RY152OCHA
MC1Rrs2228479A
MC1Rrs1110400C
SLC45A2rs28777C
SLC45A2rs16891982C
KITLGrs12821256G
EXOC2rs4959270A
IRF4rs12203592T
TYRrs1042602T
OCA2rs1800407A
SLC24A4rs2402130G
HERC2rs12913832T
ASIPrs2378249C
SLC24A4rs12896399T
TYRrs1393350T
TYRP1rs683G
 
Display Predicted Phenotype    Download Predicted Phenotype
 
Predicted phenotype

Instructions

If input allele is not present, put 0 into 'No. of alleles' box
If one is present, heterozygote, put 1 in the box
If the only allele present is the input allele, homozygote, put 2 in the box
If there is a missing SNP. please enter NA
Inputs missing HERC2 rs12913832 will not produce an eye colour prediction result.
Inputs missing all MC1R (11 SNPs) will not produce a hair colour prediction result.
Inputs missing HERC2-SLC45A2-IRF4 will not produce an eye or hair colour prediction result.

Current Database AUC values at a population level
Blue eye colour0.94
Intermediate eye colour0.74
Brown eye colour0.95
Blond hair colour0.81
Brown hair colour0.75
Red hair colour0.92
Black hair colour0.85
Hair colour shade0.90

file upload

example input file (header only, add your own data): HIrisPlex.csv

Notes

Please Note:
Partial profiles do not reflect the full prediction potential of both IrisPlex and HIrisPlex systems and should be used with caution. Also prediction values may differ from IrisPlex or HIrisPlex Excel prediction values previously published. This is due to an increase in database size for use in the underlying model for both eye and hair colour in this online tool.

References

Please cite this reference when you use the online tool in your analyses.

S. Walsh, L. Chaitanya, L. Clarisse, L. Wirken, J. Draus-Barini, L. Kovatsi, H. Maeda, T. Ishikawa, T. Sijen, P. de Knijff, W. Branicki, F. Liu, M. Kayser, Developmental validation of the HIrisPlex system: DNA-based eye and hair colour prediction for forensic and anthropological usage. Forensic Science International: Genetics. Submitted.

The initial research and development that led to this resource was supported in part by funding from the Netherlands Forensic Institute (NFI), the Erasmus MC University Medical Center Rotterdam, and by a grant from the Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO) within the framework of the Forensic Genomics Consortium Netherlands (FGCN). Development and maintenance of this web resource is supported by Erasmus MC University Medical Center Rotterdam.

There where 9421 visits since the launch of this website in january 2014
There where 326256713 phenotypes predicted since the launch of this website in januari 2014